var objElement = document.getElementById('_MBcrmFormSaveAndClose');
    objElement.innerHTML='<SPAN><SPAN><SPAN><SPAN></SPAN></SPAN></SPAN></SPAN>';
A function can be created to show/hide buttons by providing the Button Id:
// show: bool. Show = true, Hide = false
// id: string. Button Id
// tags: string. Object to stored the HTML tags
crmForm.ShowButton = function(show, id, tags)
{
    // Retrieve relevant button element based on Id
    var objElement = document.getElementById(id);
    var returnValue = null;
    // Show Button
    if (show) 
    {
        // Ensure the HTML tags for showing button is available 
        if (tags != null) 
        {
            // Restore HTML tags for showing button
            objElement.innerHTML = tags;
        }
    }
    // Hide Button
    else
    {
        // Store the HTML tags so that it can be restored when showing button
        returnValue = objElement.innerHTML;
        objElement.innerHTML='<SPAN><SPAN><SPAN><SPAN></SPAN></SPAN></SPAN></SPAN>';
    }
    return returnValue;
}
To call the function to hide a button:
    crmForm.SaveAndCloseButtonTags = crmForm.ShowButton(false, 
        "_MBcrmFormSaveAndClose", crmForm.SaveAndCloseButtonTags);
To show the button:
    crmForm.SaveAndCloseButtonTags = crmForm.ShowButton(true, 
        "_MBcrmFormSaveAndClose", crmForm.SaveAndCloseButtonTags);
To remove the button completely:
    var objElement = document.getElementById('_MBcrmFormSaveAndClose');
    objElement.outerHTML='<SPAN><SPAN><SPAN><SPAN></SPAN></SPAN></SPAN></SPAN>';
